Data Access Register - full project summary
| Application ID | LLC_0042 |
|---|---|
| Project Title | Strengthening dementia epidemiology through improved record-linked ascertainment |
| Lead Applicant | Dylan Williams |
| Organisation(s) Name(s) | University College London |
| Approval Date | 12/12/2025 |
| Application Status | Approved |
| Lay Summary | Dementia refers to problems affecting memory and other mental abilities. Dementia is becoming more common as the population ages. Dementia stems from several diseases affecting the brain; most commonly, Alzheimer’s disease (AD), which is thought to account for 50-70% of cases. A big cause of AD is a gene called APOE: perhaps more than 90% of AD would not occur without APOE’s contribution. Other things cause of AD, such as other genes and the environment in which people live. We need studies with thousands of people to find these other causes of AD. In such studies (cohorts and surveys) health measures have been collected over many years or decades, but we tend not to know which people have developed AD over time. This undermines our ability to detect and confirm causes of the disease. Here, we will put together a mix of health measures collected by cohorts and surveys alongside health records collected by the NHS. This will help us find more AD cases among study members. We will then see whether APOE shows a stronger link with AD when we look among a larger number of cases. This study will help us to find new ways of treating AD. |
| Datasets Requested | LPS Data:
Linked Datasets:
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| Results & Impact |