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Data Access Register - full project summary

Application ID LLC_0004
Project Title Examining the serological response to SARS-CoV-2 infection and vaccination across the National Core Studies
Lead Applicant Olivia Hamilton
Organisation(s) Name(s) University of Glasgow
Approval Date 28/10/2021
Application Status Approved
Lay Summary

When we catch COVID-19, or have a vaccination for COVID-19, our bodies make special substances called antibodies to tackle the virus. However, some people make fewer antibodies than others, or their antibodies disappear quicker over time. These people have less protection from COVID-19, so might benefit from a booster vaccine.

This project aims to identify groups of people who have fewer antibodies after having the COVID-19 infection, or after having the vaccine. Examples of these groups might be older people, or people who had other health problems before getting Covid. To do this, we need to link data from our research studies to NHS health record data, such as data on whether people have had COVID-19 and whether they have had a COVID-19 vaccine. We also need to know exactly when they were infected or vaccinated, so we can work out how their levels of antibodies have changed from that time onwards.

We will share the results of this project with policy makers and hope that it will inform decisions about who should be put first in the list for future COVID-19 booster vaccinations.

Datasets Requested

Study Data

  • National Survey of Health and Development 1946 Birth Cohort (NSHD)
  • Southall and Brent Revisited Study (SABRE) (non-linked data only)
  • English Longitudinal Study of Ageing (ELSA)
  • 1958 National Child Development Study (1958 NCDS)
  • British Cohort Study 1970 (BCS 70)
  • Millennium Cohort Study (MCS)
  • Twins UK
  • Extended Cohort for E-Health, Environment & DNA (EXCEED)
  • Understanding Society (UK Household Longitudinal Study)

Linked Data

  • Covid 19 Vaccination Status
  • GPES Data for Pandemic Planning and Research (COVID-19)
  • Covid-19 UK Non-Hospital Antigen Testing Results
  • Hospital Episode Statistics Critical Care
  • Hospital Episode Statistics Admitted Patient Care
  • Hospital Episode Statistics Accident and Emergency
  • COVID-19 SARI-WATCH (formerly CHESS)
  • Covid-19 Second Generation Surveillance System (Pillar 1 & Pillar 2)
  • Covid-19 UK Non-hospital Antibody Testing Results (Pillar 3)
  • Civil Registration – Deaths (England & Wales)
Results & Impact