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Data Access Register - full project summary

Application ID LLC_0030
Project Title Investigating the association of long-term air pollution exposure with risk and severity of SARS-CoV-2 infection
Lead Applicant Annalan Navaratnam
Organisation(s) Name(s) University of Cambridge
Approval Date 21/06/2024
Application Status Approved
Lay Summary

Evidence suggests that increased long-term exposure to air pollution is linked to individuals being at higher risk of being infected with COVID-19. It suggests that if a person becomes infected with COVID-19, there is a higher chance of worse symptoms and requiring more medical care if that person has been exposed to higher levels of air pollution previously.

Existing research studies have not always taken account of other potentially important factors such as underlying medical conditions and differing groups of people and locations.

By analysing data from multiple studies in different locations, and detailed information about each participant (e.g., underlying health conditions), we can find out if there is an increased risk of infection and worse outcomes from infection. We propose to investigate these links, taking into account other risk factors of COVID-19 and severity of disease, to identify the link between air pollution exposure and COVID-19 related outcomes. This will provide more strength to current calls to reduce air pollution emissions, highlighting its link to infectious diseases in addition to associated increased risk of other conditions such as asthma, heart disease and diabetes. The findings may encourage further research into the link between lung infections and air pollution exposure.

Datasets Requested

LPS Data:

  • ALSPAC
  • Born in Bradford
  • EXCEED
  • Generation Scotland
  • NIHR Bioresource
  • NSHD46
  • SABRE
  • TWINSUK

Linked Datasets

  • Demographics
  • Civil Registration – Deaths
  • Cancer Registration Data
  • Hospital Episode Statistics Admitted Patient Care
  • Hospital Episode Statistics Augmented/Critical Care
  • Hospital Episode Statistics Outpatient
  • Hospital Episode Statistics Accident and Emergency
  • Emergency Care Data Set (ECDS)
  • GDPPR Data for Pandemic Planning and Research
  • COVID-19 Vaccination Status
  • COVID-19 SARI-WATCH
  • COVID-19 Second Generation Surveillance System
  • COVID-19 NPex
  • COVID-19 UK Non-hospital Antibody Testing Results

Other Datasets:

  • Harmonised Sociodemographic data
  • Air pollution data (annual averages of NO2 and PM2.5)
Results & Impact